Publications
Revue · Will the next generation of chemical plants be in miniaturized flow reactors?, J.-C. M. Monbaliu, J. Legros, Lab Chip, 2023, 23, 1349 ; DOI : https://doi.org/10.1039/d2lc00796g
Article · Flow platform for the synthesis of benzodiazepines, M. Ivanova, T. Poisson, P. Jubault, J. Legros, J. Flow. Chem., 2023, 13, 45 ; DOI : https://doi.org/10.1007/s41981-022-00243-z
Article · Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene, M. Ivanova, T. Poisson, P. Jubault, J. Legros, J. Flow. Chem., 2022, 12, 147 ; DOI : https://doi.org/10.1007/s41981-021-00205-x
Article · Flow synthesis of an α-amino boronic ester as a key precursor of bortezomib drug, T. Desrues, J. Legros, P. Jubault, T. Poisson, React. Chem. Eng., 2022, 7, 1285 ; DOI : https://doi.org/10.1039/D2RE00099G
Article · Continuous Flow Synthesis of Propofol, R. Mougeot, J. Legros, P. Jubault, T. Poisson, Molecules, 2021, 26, 7183 ; DOI : https://doi.org/10.3390/molecules26237183
Article · Synthesis of N-heterocyclic amides from imidazoheterocycles through convergent paired electrolysis, E. Leclercq, N. David, M. Durandetti, L. Chausset-Boissarie, Org. Biomol. Chem. 2024, 22, 8730 ; DOI : https://doi.org/10.1039/D4OB01115E
Article · Electrochemical Trifluoromethylalkoxylation of Endocyclic Enamides in Batch and Flow, E. Leclercq, W. Barakat, R. Maazaoui, M. Penhoat, I. Gillaizeau, L. Chausset-Boissarie, Adv. Synth. Catal., 2024, 366, 2919 ; DOI : https://doi.org/10.1002/adsc.202301485
Article · Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study, R. Lapierre, T. M. Thi Le, B. Schiavi, D. Thevenet, M. Bazin, R. Buzdygon, P. Jubault, T. Poisson, Org. Process Res. Dev., 2024, 28, 1346 ; DOI : https://doi.org/10.1021/acs.oprd.2c00379
Revue · Photocatalytic and Electrochemical Borylation and Silylation Reactions, T. Biremond, M. Riomet, P. Jubault, T. Poisson, Chem. Rec., 2023, 23, e202300172 ; DOI : https://doi.org/10.1002/tcr.202300172
Article · Electrochemical Synthesis of gem-Difluoro- and γ-Fluoro-Allyl Boronates and Silanes, M. Aelterman, T. Biremond, P. Jubault, T. Poisson, Chem. Eur. J., 2022, 28, e202202194 ; DOI : https://doi.org/10.1002/chem.202202194
Article · An electrolyte free electrochemical C-H trifluoromethylation of 2-pyridones under batch and flow conditions, E. Leclercq, A. Moncomble, C. Debavelaere, M. Beaucamp, M. Penhoat, L. Chausset-Boissarie, Green Chem., 2022, 24, 7388 ; DOI : https://doi.org/10.1039/D2GC02326A
Article · Electrochemical sulfonylation of imidazoheterocycles in Batch and continuous Flow, E. Leclercq, M. Boddaert, M. Beaucamp, M. Penhoat, L. Chausset-Boissarie, Org. Biomol. Chem. 2021, 19, 9379 ; DOI : https://doi.org/10.1039/D1OB01822A
Article · Excited-state configuration of nitroarenes enables oxidative cleavage of aromatics over alkenes, W. J. Olivier, P. Błyszczyk, E. M. Arpa, K. Hitoshio, M. Gomez-Mendoza, V. de la Peña O’Shea, I. Marchand, T. Poisson, A. Ruffoni, D. Leonori, Science, 2025, 387, 1167 ; DOI : https://doi.org/10.1126/science.ads3955
Article · Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study, R. Lapierre, T. M. Thi Le, B. Schiavi, D. Thevenet, M. Bazin, R. Buzdygon, P. Jubault, T. Poisson, Org. Process Res. Dev., 2024, 28, 1346 ; DOI : https://doi.org/10.1021/acs.oprd.2c00379
Article · Photocatalyzed (3 + 2) Cycloaddition for the Dearomatization of Electron-Poor Arenes under Flow Conditions, Y. Faye, B. Rkein, A. Bigot, T. Lequeux, J. Legros, I. Chataigner, Chem. Eur. J., 2023, 29, e202301567 ; DOI : https://doi.org/10.1002/chem.202301567
Revue · Photocatalytic and Electrochemical Borylation and Silylation Reactions, T. Biremond, M. Riomet, P. Jubault, T. Poisson, Chem. Rec., 2023, 23, e202300172 ; DOI : https://doi.org/10.1002/tcr.202300172
Article · Multiple wavelength (365 – 475 nm) complete actinometric characterization of Corning® Labphoto Reactor using azobenzene as a highly soluble, cheap and robust chemical actinometer, M. Roseau, L. Chausset-Boissarie, S. Gremetz, P. M. C. Roth, M. Penhoat, Photochem Photobiol Sci, 2022, 21, 421 ; DOI : https://doi.org/10.1007/s43630-022-00171-w
Article · Copper-Photocatalyzed Hydrosilylation of Alkynes and Alkenes under Continuous Flow, M. Zhong, X. Pannecoucke, P. Jubault, T. Poisson, Chem. Eur. J., 2021, 27, 11818 ; DOI : https://doi.org/10.1002/chem.202101753
Article · Azobenzene: a visible-light chemical actinometer for the characterization of fluidic photosystems, M. Roseau, V. De Waele, X. Trivelli, F.-X. Cantrelle, M. Penhoat, L. Chausset-Boissarie, Helv. Chim. Acta 2021, 104, e2100071 ; DOI : https://doi.org/10.1002/hlca.202100071
Article · Copper-Photocatalyzed Hydroboration of Alkynes and Alkenes, M. Zhong, Y. Gagné, T. O. Hope, X. Pannecoucke, M. Frenette, P. Jubault, T. Poisson, Angew. Chem. Int. Ed., 2021, 60, 14498 ; DOI : https://doi.org/10.1002/anie.202101874
Article · Metal Free ATRP Catalyzed by Visible Light in Continuous Flow, N. El Achi, Y. Bakkour, W. Adhami, J. Molina, M. Penhoat, N. Azaroual, L. Chausset-Boissarie, C. Rolando, Front. Chem., 2020, 8, 740 ; DOI : https://doi.org/10.3389/fchem.2020.00740
Article · Continuous photocatalyzed aerobic oxidation of benzylic organotrifluoroborates to benzaldehydes under Taylor flow conditions, M. Roseau, N. Dhaouadi, C. Rolando, L. Chausset-Boissarie, M. Penhoat, J. Flow Chem., 2020, 10, 347 ; DOI : https://doi.org/10.1007/s41981-019-00053-w
Revue · Microfluidique pour la photochimie, L. Chausset-Boissarie, Techniques de l’ingénieur, Chem., 2019, Réf : J8050 v1 ; DOI : https://doi.org/10.51257/a-v1-j8050
Article · Sensitized [2+2] intramolecular photocycloaddition of unsaturated enones using UV LEDs in a continuous flow reactor: kinetics and preparative aspect, N. El Achi, N. Gelat, N. P. Cheval, A. Mazzah, Y. Bakkour, M. Penhoat, L. Chausset-Boissarie, C. Rolando, React. Chem. Eng. 2019, 4, 828 ; DOI : https://doi.org/10.1039/C8RE00314A
Article · UV-mediated hydrophosphinylation of unactivated alkenes with phosphinates under batch and flow conditions, F. Gelat, M. Roger, C. Penverne, A. Mazzad, C. Rolando, L. Chausset-Boissarie, RSC Adv. 2018, 8, 8385 ; DOI : https://doi.org/10.1039/C7RA12977G
Article · Rapid and Facile Chemical Actinometric Protocol for Photomicrofluidic Systems using Azobenzene and NMR Spectroscopy, N. El Achi, Y. Bakkour, L. Chausset-Boissarie, M. Penhoat, C. Rolando, RSC Adv. 2017, 7, 29815 ; DOI : https://doi.org/10.1039/C7RA01237C
Article · Continuous UV‐Flow Microsystem for Efficient Radical Generation from Organotrifluoroborates by Photoredox Catalysis, N. El Achi, M. Penhoat, Y. Bakkour, C. Rolando, L. Chausset-Boissarie, Eur. J. Org. Chem. 2016, 25, 4284 ; DOI : https://doi.org/10.1002/ejoc.201600728
Citation · Some Items of Interest to Process R&D Chemists and Engineers, A. A. Zlota, A. Steven, C. Mateos, P. F. Richardson, R. B. Kargbo, T. Verheyen, C. C. Nawrat, D. S. B. Daniels, A. Barthelme, S. Guizzetti, J. Knight, Org. Process Res. Dev., 2025 ; DOI : https://doi.org/10.1021/acs.oprd.5c00064
Article · Continuous Flow Synthesis of α-Chloroketones from Esters, L. Brassart, M. Manneveau, T. Poisson, J. Legros, P. Huez, M. Forcato, P. Jubault, L. Chausset-Boissarie, Adv. Synth. Catal., 2025, 367, e202401438 ; DOI : https://doi.org/10.1002/adsc.202401438
Article · Flow detoxification of a sulfur mustard simulant with organometallic compounds enabled by an optimization algorithm, V. B. Silva, S. Mansour, A. Delaune, F.-X. Felpin, J. Legros, React. Chem. Eng., 2023, 8, 2658 ; DOI : https://doi.org/10.1039/D3RE00264K
Article · Anionic synthesis and end-functionalization of polymyrcene in a flow microreactor system, K. Pérez, S. Leveneur, F. Burel, J. Legros, D. Vuluga, React. Chem. Eng., 2023, 8, 432 ; DOI : https://doi.org/10.1039/D2RE00288D
Article · Continuous-Flow Divergent Lithiation of 2,3-Dihalopyridines: Deprotolithiation versus Halogen Dance, T. Brégent, M. Ivanova, T.Poisson, P. Jubault, J. Legros, Chem. Eur .J., 2022, 28, e2022022 ; DOI : https://doi.org/10.1002/chem.202202286
Article · Bromine–Lithium Exchange on a gem-Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers, K. Pérez, B. Picard, D. Vuluga, F. Burel, R. Hreiz, L. Falk, J.-M. Commenge, A. Nagaki, J.-I. Yoshida, I. Chataigner, J. Maddaluno, J. Legros, Org. Process Res. Dev., 2020, 24, 787 ; DOI : https://doi.org/10.1021/acs.oprd.0c00203
Article · Bromine-lithium exchange on gem-dibromoalkenes part 1: batch vs microflow conditions, B. Picard, K. Pérez, T. Lebleu, D. Vuluga, F. Burel, D. C. Harrowven, I. Chataigner, J. Maddaluno, J. Legros, J. Flow. Chem., 2020, 10, 139 ; DOI : https://doi.org/10.1007/s41981-019-00057-6
Revue · Chimie éclair – Synthèse microfluidique ultra-rapide, B. Picard, J. Legros, Techniques de l’ingénieur, 2020, Réf : J8035 v1 ; DOI : https://doi.org/10.51257/a-v1-j8035
Article · Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor, M. Boddaert, V. Baptista da Silva, S. Mansour, D. Vuluga, P.-Y. Renard, J.-C. M. Monbaliu, J. Legros, Chem. Eur. J., 2025, e202403701 ; DOI : https://doi.org/10.1002/chem.202403701
Article · A miniaturized ozonolysis flow platform for expeditious sulfur mustard warfare simulant neutralization, M. Boddaert, P. Bianchi, D. V. Silva-Brenes, A. Musina, M. Winter, P. M. C. Roth, P.-Y. Renard, J. Legros, J.-C. M. Monbaliu, Green Chem., 2024, 26, 1281 ; DOI : https://doi.org/10.1039/D3GC03470D
Article · Flow detoxification of a sulfur mustard simulant with organometallic compounds enabled by an optimization algorithm, V. B. Silva, S. Mansour, A. Delaune, F.-X. Felpin, J. Legros, React. Chem. Eng., 2023, 8, 2658 ; DOI : https://doi.org/10.1039/D3RE00264K
Revue · Organophosphorus chemical security from a peaceful perspective: sustainable practices in its synthesis, decontamination and detection, V. B. Silva, Y. H. Santos, R. Hellinger, S. Mansour, A. Delaune, J. Legros, S. Zinoviev, E. S. Nogueira, E. S. Orth,
Green Chem., 2022, 24, 585 ; DOI : https://doi.org/10.1039/D1GC02705K
Article · Soft and effective detoxification of a VX simulant in a nylon 3D printed basic flow reactor, S. Mansour, A. Delaune, M. Manneveau, B. Picard, A. Claudel, C. Vallières, L. Sigot, P.-Y. Renard, J. Legros, Green Chem., 2021, 23, 7522 ; DOI : https://doi.org/10.1039/D1GC01961A
Article · Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed bed vs. aqueous solution, A. Delaune, S. Mansour, B. Picard, P. Carrasqueira, I. Chataigner, L. Jean, P.-Y. Renard, J.-C. M. Monbaliu, J. Legros, Green Chem., 2021, 23, 2925 ; DOI : https://doi.org/10.1039/D1GC00449B
Article · Oxidative Neutralization of Mustard-Gas Simulants in an On-Board Flow Device with In-Line NMR Monitoring, B. Picard, B. Gouilleux, T. Lebleu, J. Maddaluno, I. Chataigner, M. Penhoat, F.-X. Felpin, P. Giraudeau, J. Legros, Angew. Chem. Int. Ed., 2017, 56, 7568 ; DOI : https://doi.org/10.1002/anie.201702744
Article · Biocatalyst and continuous microfluidic reactor for an intensified production of n-butyl levulinate: Kinetic model assessment, A. Cordier, M. Klinksiek, C. Held, J. Legros, S. Leveneur, Chem. Eng. J., 2023, 451, 13854126 ; DOI : https://doi.org/10.1016/j.cej.2022.138541
Article · Flow dearomatization of electron-poor 3-fluoromethylthioindoles by 1,3-dipolar cycloaddition, M. Manneveau, B. Rkein, D. Cahard, J. Legros, I. Chataigner, J. Flow. Chem., 2022 12, 141 ; DOI : https://doi.org/10.1007/s41981-021-00203-z
Article · Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry, M. Manneveau, S. Tanii, F. Gens, J. Legros, I. Chataigner,
Org. Biomol. Chem., 2020, 18, 3481 ; DOI : https://doi.org/10.1039/D0OB00582G
