{"id":118,"date":"2023-09-22T19:01:02","date_gmt":"2023-09-22T17:01:02","guid":{"rendered":"https:\/\/normandyflowchem.univ-rouen.fr\/?page_id=118"},"modified":"2026-07-15T09:44:32","modified_gmt":"2026-07-15T07:44:32","slug":"realisations","status":"publish","type":"page","link":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/realisations\/","title":{"rendered":"Realisations"},"content":{"rendered":"\n

Publications<\/p>\n\n\n\n

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Synth\u00e8se de principes actifs pharmaceutiques en flux continu<\/h2><\/div>\n\n\n\n
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Article<\/span> \u00b7 Process Intensified Continuous Flow Synthesis of Propofol<\/strong>, A. Coeuillas<\/span>, A. Ceuninck<\/span>, L. Chausset-Boissarie<\/span>, J. Legros<\/span>, P. Jubault<\/span>, T. Poisson<\/span>, Org. Process Res. Dev.<\/em> 2026<\/strong>, XXXX, XXX, XXX-XXX, DOI : https:\/\/doi.org\/10.1021\/acs.oprd.6c00151<\/a><\/p><\/div>\n\n\n\n

Revue<\/span> \u00b7 Will the next generation of chemical plants be in miniaturized flow reactors?<\/strong>, J.-C. M. Monbaliu, J. Legros<\/span>, Lab Chip<\/em>, 2023<\/strong>, 23, 1349 ; DOI : https:\/\/doi.org\/10.1039\/d2lc00796g<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Flow platform for the synthesis of benzodiazepines<\/strong>, M. Ivanova<\/span>, T. Poisson<\/span>, P. Jubault<\/span>, J. Legros<\/span>, J. Flow. Chem.<\/em>, 2023<\/strong>, 13, 45 ; DOI : https:\/\/doi.org\/10.1007\/s41981-022-00243-z<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene<\/strong><\/strong>, M. Ivanova<\/span>, T. Poisson<\/span>, P. Jubault<\/span>,<\/em> J. Legros<\/span>, J. Flow. Chem.<\/em>, 2022<\/strong>, 12, 147 ; DOI : https:\/\/doi.org\/10.1007\/s41981-021-00205-x<\/a><\/p>\n\n\n\n

Article<\/span> \u00b7 Flow synthesis of an \u03b1-amino boronic ester as a key precursor of bortezomib drug<\/strong><\/strong>, T. Desrues<\/span>, J. Legros<\/span>, P. Jubault<\/span>, T. Poisson<\/span>, React. Chem. Eng.,<\/em> 2022<\/strong>, 7, 1285 ; DOI : <\/a>https:\/\/doi.org\/10.1039\/D2RE00099G<\/a><\/p>\n\n\n\n

Article<\/span> \u00b7 A multi-step continuous flow synthesis of pomalidomide<\/strong><\/strong>, M. Ivanova<\/span>, J. Legros<\/span>, T. Poisson<\/span>, P. Jubault<\/span>, J<\/em>. Flow. Chem<\/em>., 2022<\/strong>, 12, 383 ; DOI : https:\/\/doi.org\/10.1039\/D2RE00099G<\/a><\/p>\n\n\n\n

Article<\/span> \u00b7 Continuous Flow Synthesis of Propofol<\/strong><\/strong><\/strong>, R. Mougeot<\/span>, J. Legros<\/span>, P. Jubault<\/span>, T. Poisson<\/span>, Molecules,<\/em> 2021<\/strong>, 26, 7183 ; DOI : https:\/\/doi.org\/10.1007\/s41981-022-00223-3<\/a><\/p>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n

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Activation \u00e9lectrochimique<\/h2><\/div>\n\n\n\n
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Article<\/span> \u00b7 Synthesis of N-heterocyclic amides from imidazoheterocycles through convergent paired electrolysis<\/strong><\/strong>, E. Leclercq<\/span>, N. David, M. Durandetti, L. Chausset-Boissarie<\/span>, Org. Biomol. Chem.<\/em> 2024<\/strong>, 22, 8730 ; DOI : https:\/\/doi.org\/10.1039\/D4OB01115E<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Electrochemical Trifluoromethylalkoxylation of Endocyclic Enamides in Batch and Flow<\/strong><\/strong>, E. Leclercq, W. Barakat, R. Maazaoui, M. Penhoat, I. Gillaizeau, L. Chausset-Boissarie<\/span>, Adv. Synth. Catal., <\/em>2024<\/strong>, <\/em>366, <\/em>2919 ; DOI : https:\/\/doi.org\/10.1002\/adsc.202301485<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study<\/strong><\/strong>, R. Lapierre, T. M. Thi Le, B. Schiavi, D. Thevenet, M. Bazin, R. Buzdygon, P. Jubault<\/span>, T. Poisson<\/span>, Org. Process Res. Dev.<\/em>, 2024<\/strong>, 28, 1346 ; DOI : https:\/\/doi.org\/10.1021\/acs.oprd.2c00379<\/a><\/p><\/div>\n\n\n\n

Revue<\/span> \u00b7 Photocatalytic and Electrochemical Borylation and Silylation Reactions<\/strong><\/strong>, T. Biremond, M. Riomet, P. Jubault<\/span>, T. Poisson<\/span>, Chem. Rec.<\/em>, 2023<\/strong>, 23, e202300172 ; DOI : https:\/\/doi.org\/10.1002\/tcr.202300172<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Electrochemical Synthesis of gem<\/em>-Difluoro- and \u03b3-Fluoro-Allyl Boronates and Silanes<\/strong><\/strong>, M. Aelterman, T. Biremond, P. Jubault<\/span>, T. Poisson<\/span>, Chem. Eur. J.<\/em>, 2022<\/strong>, 28, e202202194 ; DOI : https:\/\/doi.org\/10.1002\/chem.202202194<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 An electrolyte free electrochemical C-H trifluoromethylation of 2-pyridones under batch and flow conditions<\/strong><\/strong>, E. Leclercq, A. Moncomble, C. Debavelaere, M. Beaucamp, M. Penhoat, L. Chausset-Boissarie<\/span>, Green Chem<\/em>., 2022<\/strong>, 24, 7388 ; DOI : https:\/\/doi.org\/10.1039\/D2GC02326A<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Electrochemical sulfonylation of imidazoheterocycles in Batch and continuous Flow<\/strong><\/strong>, E. Leclercq, M. Boddaert, M. Beaucamp, M. Penhoat, L. Chausset-Boissarie<\/span>, Org. Biomol. Chem.<\/em> 2021<\/strong>, 19, 9379 ; DOI : https:\/\/doi.org\/10.1039\/D1OB01822A<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n

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Activation photochimique<\/h2><\/div>\n\n\n\n
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Article<\/span> \u00b7 A photochemical strategy for pyrazole to imidazole conversion<\/strong><\/strong>, Y. Wei, A. Igartua, D. B. Yildiz, A. Ceuninck<\/span>, T. dos Santos, C. B\u00fcttner, D. Thevenet Author, M. Bossart, V. Derdau, M. Mendez Perez, P. Jubault<\/span>, T. Poisson<\/span>, B. Roure, D. Leonori, ChemRxiv<\/em>, 2025<\/strong>, DOI : https:\/\/doi.org\/10.26434\/chemrxiv-2026-68vcj<\/a> ; this content is a preprint and has not been peer-reviewed.<\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Excited-state configuration of nitroarenes enables oxidative cleavage of aromatics over alkenes<\/strong><\/strong>, W. J. Olivier, P. B\u0142yszczyk, E. M. Arpa, K. Hitoshio, M. Gomez-Mendoza, V. de la Pe\u00f1a O\u2019Shea, I. Marchand<\/span>, T. Poisson<\/span>, A. Ruffoni, D. Leonori, Science<\/em>, 2025<\/strong>, 387, 1167 ; DOI : https:\/\/doi.org\/10.1126\/science.ads3955<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Photocatalytic and Photoinduced Phosphonylation of Aryl Iodides: A Batch and Flow Study<\/strong><\/strong>, R. Lapierre, T. M. Thi Le, B. Schiavi, D. Thevenet, M. Bazin, R. Buzdygon, P. Jubault<\/span>, T. Poisson<\/span>, Org. Process Res. Dev.<\/em>, 2024<\/strong>, 28, 1346 ; DOI : https:\/\/doi.org\/10.1021\/acs.oprd.2c00379<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Photocatalyzed (3 + 2) Cycloaddition for the Dearomatization of Electron-Poor Arenes under Flow Conditions<\/strong><\/strong>, Y. Faye, B. Rkein, A. Bigot, T. Lequeux, J. Legros<\/span>, I. Chataigner, Chem. Eur. J<\/em>., 2023<\/strong>, 29, e202301567 ; DOI : https:\/\/doi.org\/10.1002\/chem.202301567<\/a><\/p><\/div>\n\n\n\n

Revue<\/span> \u00b7 Photocatalytic and Electrochemical Borylation and Silylation Reactions<\/strong><\/strong>, T. Biremond, M. Riomet, P. Jubault<\/span>, T. Poisson<\/span>, Chem. Rec.<\/em>, 2023<\/strong>, 23, e202300172 ; DOI : https:\/\/doi.org\/10.1002\/tcr.202300172<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Multiple wavelength (365 \u2013 475 nm) complete actinometric characterization of Corning\u00ae Labphoto Reactor using azobenzene as a highly soluble, cheap and robust chemical actinometer<\/strong><\/strong>, M. Roseau, L. Chausset-Boissarie<\/span>, S. Gremetz, P. M. C. Roth, M. Penhoat, Photochem Photobiol Sci, <\/em>2022<\/strong>, <\/em>21, 421 ; DOI : https:\/\/doi.org\/10.1007\/s43630-022-00171-w<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Copper-Photocatalyzed Hydrosilylation of Alkynes and Alkenes under Continuous Flow<\/strong><\/strong>, M. Zhong, X. Pannecoucke, P. Jubault<\/span>, T. Poisson<\/span>, Chem. Eur. J<\/em>., 2021<\/strong>, 27, 11818 ; DOI : https:\/\/doi.org\/10.1002\/chem.202101753<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Azobenzene: a visible-light chemical actinometer for the characterization of fluidic photosystems<\/strong><\/strong>, M. Roseau, V. De Waele, X. Trivelli, F.-X. Cantrelle, M. Penhoat, L. Chausset-Boissarie<\/span>, Helv. Chim. Acta <\/em>2021<\/strong>, 104, e2100071 ; DOI : https:\/\/doi.org\/10.1002\/hlca.202100071<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Copper-Photocatalyzed Hydroboration of Alkynes and Alkenes<\/strong><\/strong>, M. Zhong, Y. Gagn\u00e9, T. O. Hope, X. Pannecoucke, M. Frenette, P. Jubault<\/span>, T. Poisson<\/span>, Angew. Chem. Int. Ed.<\/em>, 2021<\/strong>, 60, 14498 ; DOI : https:\/\/doi.org\/10.1002\/anie.202101874<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Metal Free ATRP Catalyzed by Visible Light in Continuous Flow<\/strong><\/strong>, N. El Achi, Y. Bakkour, W. Adhami, J. Molina, M. Penhoat, N. Azaroual, L. Chausset-Boissarie<\/span>, C. Rolando, Front. Chem<\/em>., 2020<\/strong>, 8, 740 ; DOI : https:\/\/doi.org\/10.3389\/fchem.2020.00740<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Continuous photocatalyzed aerobic oxidation of benzylic organotrifluoroborates to benzaldehydes under Taylor flow conditions<\/strong><\/strong>, M. Roseau, N. Dhaouadi, C. Rolando, L. Chausset-Boissarie<\/span>, M. Penhoat, J. Flow Chem.<\/em>, 2020<\/strong>, 10, 347 ; DOI : https:\/\/doi.org\/10.1007\/s41981-019-00053-w<\/a><\/p><\/div>\n\n\n\n

Revue<\/span> \u00b7 Microfluidique pour la photochimie<\/strong>, L. Chausset-Boissarie<\/span>, Techniques de l’ing\u00e9nieur<\/em>, Chem.<\/em>, 2019<\/strong>, R\u00e9f : J8050 v1 ; DOI : https:\/\/doi.org\/10.51257\/a-v1-j8050<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Sensitized [2+2] intramolecular photocycloaddition of unsaturated enones using UV LEDs in a continuous flow reactor: kinetics and preparative aspect<\/strong><\/strong>, N. El Achi, N. Gelat, N. P. Cheval, A. Mazzah, Y. Bakkour, M. Penhoat, L. Chausset-Boissarie<\/span>, C. Rolando, React. Chem. Eng. <\/strong><\/em>2019<\/strong>, 4, 828 ; DOI : https:\/\/doi.org\/10.1039\/C8RE00314A<\/a><\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 UV-mediated hydrophosphinylation of unactivated alkenes with phosphinates under batch and flow conditions<\/strong><\/strong>, F. Gelat, M. Roger, C. Penverne, A. Mazzad, C. Rolando, L. Chausset-Boissarie<\/span>, RSC Adv. <\/em>2018<\/strong>, <\/em>8, <\/em>8385 ; DOI : https:\/\/doi.org\/10.1039\/C7RA12977G<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Rapid and Facile Chemical Actinometric Protocol for Photomicrofluidic Systems using Azobenzene and NMR Spectroscopy<\/strong><\/strong>, N. El Achi, Y. Bakkour, L. Chausset-Boissarie<\/span>, M. Penhoat, C. Rolando, RSC Adv.<\/em> 2017<\/strong>, 7, 29815 ; DOI : https:\/\/doi.org\/10.1039\/C7RA01237C<\/a><\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Continuous UV\u2010Flow Microsystem for Efficient Radical Generation from Organotrifluoroborates by Photoredox Catalysis<\/strong><\/strong>, N. El Achi, M. Penhoat, Y. Bakkour, C. Rolando, L. Chausset-Boissarie<\/span>, Eur. J. Org. Chem.<\/em> 2016<\/strong>, 25, 4284 ; DOI : https:\/\/doi.org\/10.1002\/ejoc.201600728<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n

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Chimie des compos\u00e9s organom\u00e9talliques<\/h2><\/div>\n\n\n\n
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Article<\/span> \u00b7 Development and Scale-Up of a Regioselective Functionalization of 2-Cyano-3-Fluoropyridine in a Flow Reactor<\/strong>, L. Brassart<\/span>, A. Coeuillas<\/span>, M. Manneveau,<\/span> T. Poisson<\/span>,<\/span> J. Legros, <\/span>P. Huez, M. Forcato, <\/span>P. Jubault<\/span>, <\/span>L. Chausset-Boissarie<\/span>, ChemRxiv<\/em>, 2025<\/strong>, DOI : https:\/\/doi.org\/10.26434\/chemrxiv.15001640\/v1<\/a> ; this content is a preprint and has not been peer-reviewed.<\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Taming the Halogen Dance of Bromo(Thi)azoles by Mean of Flow Microreactors<\/strong>, B. Ozveren<\/span>, A. Coeuillas<\/span>, P. Jubault<\/span>, L. Chausset-Boissarie<\/span>, T. Poisson<\/span>, J. Legros<\/span>, ChemRxiv<\/em>, 2025<\/strong>, DOI : https:\/\/doi.org\/10.26434\/chemrxiv-2025-410sm<\/a> ; this content is a preprint and has not been peer-reviewed.<\/p><\/div>\n\n\n\n

Citation<\/span> \u00b7 Some Items of Interest to Process R&D Chemists and Engineers<\/strong>, A. A. Zlota, A. Steven, C. Mateos, P. F. Richardson, R. B. Kargbo, T. Verheyen, C. C. Nawrat, D. S. B. Daniels, A. Barthelme, S. Guizzetti, J. Knight, Org. Process Res. Dev.<\/em><\/em>, 2025<\/strong> ; DOI : https:\/\/doi.org\/10.1021\/acs.oprd.5c00064<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Continuous Flow Synthesis of \u03b1-Chloroketones from Esters<\/strong>, L. Brassart<\/span>, M. Manneveau, T. Poisson<\/span>, J. Legros<\/span>, P. Huez, M. Forcato, P. Jubault<\/span>, L. Chausset-Boissarie<\/span>, Adv. Synth. Catal.<\/em>, 2025<\/strong>, 367, e202401438 ; DOI : https:\/\/doi.org\/10.1002\/adsc.202401438<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Flow detoxification of a sulfur mustard simulant with organometallic compounds enabled by an optimization algorithm<\/strong>, V. B. Silva<\/span>, S. Mansour, A. Delaune, F.-X. Felpin, J. Legros<\/span>, React. Chem. Eng.<\/em>, 2023<\/strong>, 8, 2658 ; DOI : <\/a>https:\/\/doi.org\/10.1039\/D3RE00264K<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Anionic synthesis and end-functionalization of polymyrcene in a flow microreactor system<\/strong>, K. P\u00e9rez<\/span>, S. Leveneur, F. Burel, J. Legros<\/span>, D. Vuluga, React. Chem. Eng.<\/em>, 2023<\/strong>, 8, 432 ; DOI : https:\/\/doi.org\/10.1039\/D2RE00288D<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Continuous-Flow Divergent Lithiation of 2,3-Dihalopyridines: Deprotolithiation versus Halogen Dance<\/strong>, T. Br\u00e9gent<\/span>, M. Ivanova<\/span>, T.Poisson,<\/span> P. Jubault<\/span>,<\/em> J. Legros,<\/span> Chem. Eur .J.<\/em>, 2022<\/strong>, 28, e2022022 ; DOI : https:\/\/doi.org\/10.1002\/chem.202202286<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Bromine\u2013Lithium Exchange on a gem<\/em>-Dibromoalkene, Part 2: Comparative Performance of Flow Micromixers<\/strong>, K. P\u00e9rez<\/span>, B. Picard, D. Vuluga, F. Burel, R. Hreiz, L. Falk, J.-M. Commenge, A. Nagaki, J.-I. Yoshida, I. Chataigner, J. Maddaluno, J. Legros<\/span>, Org. Process Res. Dev.<\/em>, 2020<\/strong>, 24, 787 ; DOI : https:\/\/doi.org\/10.1021\/acs.oprd.0c00203<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Bromine-lithium exchange on gem<\/em>-dibromoalkenes part 1: batch vs microflow conditions<\/strong>, B. Picard, K. P\u00e9rez<\/span>, T. Lebleu, D. Vuluga, F. Burel, D. C. Harrowven, I. Chataigner, J. Maddaluno, J. Legros<\/span>, J. Flow. Chem.,<\/em> 2020,<\/strong> 10, 139 ; DOI : https:\/\/doi.org\/10.1007\/s41981-019-00057-6<\/a><\/p><\/div>\n\n\n\n

Revue <\/span>\u00b7 Chimie \u00e9clair – Synth\u00e8se microfluidique ultra-rapide<\/strong>, B. Picard, J. Legros<\/span>, Techniques de l’ing\u00e9nieur,<\/em> 2020,<\/strong> R\u00e9f : J8035 v1 ; DOI : https:\/\/doi.org\/10.51257\/a-v1-j8035<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n

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D\u00e9contamination d’armes chimiques<\/h2><\/div>\n\n\n\n
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Article<\/span> \u00b7 Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor<\/strong>, M. Boddaert<\/span>, V. Baptista da Silva<\/span>, S. Mansour<\/span>, D. Vuluga, P.-Y. Renard, J.-C. M. Monbaliu, J. Legros<\/span>, Chem. Eur. J<\/em>., 2025<\/strong>, e202403701 ; DOI : https:\/\/doi.org\/10.1002\/chem.202403701<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 A miniaturized ozonolysis flow platform for expeditious sulfur mustard warfare simulant neutralization<\/strong>, M. Boddaert<\/span>, P. Bianchi, D. V. Silva-Brenes, A. Musina, M. Winter, P. M. C. Roth, P.-Y. Renard, J. Legros<\/span>, J.-C. M. Monbaliu, Green Chem.<\/em>, 2024<\/strong>, 26, 1281 ; DOI : https:\/\/doi.org\/10.1039\/D3GC03470D<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Flow detoxification of a sulfur mustard simulant with organometallic compounds enabled by an optimization algorithm<\/strong>, V. B. Silva<\/span>, S. Mansour<\/span>, A. Delaune<\/span>, F.-X. Felpin, J. Legros<\/span>, React. Chem. Eng.<\/em>, 2023<\/strong>, 8, 2658 ; DOI : <\/a>https:\/\/doi.org\/10.1039\/D3RE00264K<\/a><\/p><\/div>\n\n\n\n

Revue<\/span> \u00b7 Organophosphorus chemical security from a peaceful perspective: sustainable practices in its synthesis, decontamination and detection<\/strong>, V. B. Silva<\/span>, Y. H. Santos, R. Hellinger, S. Mansour<\/span>, A. Delaune<\/span>, J. Legros<\/span>, S. Zinoviev, E. S. Nogueira, E. S. Orth,
<\/strong>Green Chem.<\/em>, 2022<\/strong>, 24, 585 ; DOI : https:\/\/doi.org\/10.1039\/D1GC02705K<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Soft and effective detoxification of a VX simulant in a nylon 3D printed basic flow reactor<\/strong>, S. Mansour<\/span>, A. Delaune<\/span>, M. Manneveau<\/span>, B. Picard<\/span>, A. Claudel, C. Valli\u00e8res, L. Sigot, P.-Y. Renard, J. Legros<\/span>, Green Chem.<\/em>, 2021<\/strong>, 23, 7522 ; DOI : <\/a>https:\/\/doi.org\/10.1039\/D1GC01961A<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Flow neutralisation of sulfur-containing chemical warfare agents with Oxone: packed bed vs.<\/em> aqueous solution<\/strong>, A. Delaune<\/span>, S. Mansour<\/span>, B. Picard<\/span>, P. Carrasqueira, I. Chataigner, L. Jean, P.-Y. Renard, J.-C. M. Monbaliu, J. Legros<\/span>, Green Chem.<\/em>, 2021<\/strong>, 23, 2925 ; DOI : https:\/\/doi.org\/10.1039\/D1GC00449B<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Oxidative Neutralization of Mustard-Gas Simulants in an On-Board Flow Device with In-Line NMR Monitoring<\/strong>, B. Picard<\/span>, B. Gouilleux, T. Lebleu, J. Maddaluno, I. Chataigner, M. Penhoat, F.-X. Felpin, P. Giraudeau, J. Legros<\/span>, Angew. Chem. Int. Ed.<\/em>, 2017<\/strong>, 56, 7568 ; DOI : https:\/\/doi.org\/10.1002\/anie.201702744<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n

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Autres th\u00e9matiques<\/h2><\/div>\n\n\n\n
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Article<\/span> \u00b7 Fluoroform upcycling to trifluorovinylamine as a C2 reagent to prepare difluoromethylated molecules<\/strong>, P. Ivashkin<\/span>, J. Decaens<\/span>, I. Marchand<\/span>, M. Hedouin, H. Oulyadi, T. Poisson<\/span>, P. Jubault<\/span>, Nat. Synth<\/em><\/em>., 2026<\/strong>, DOI : https:\/\/www.nature.com\/articles\/s44160-026-01001-y<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Biocatalyst and continuous microfluidic reactor for an intensified production of n-butyl levulinate: Kinetic model assessment<\/strong>, A. Cordier<\/span>, M. Klinksiek, C. Held, J. Legros<\/span>, S. Leveneur, Chem. Eng. J.<\/em>, 202<\/strong>3, 451, 13854126 ; DOI : https:\/\/doi.org\/10.1016\/j.cej.2022.138541<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Flow dearomatization of electron-poor 3-fluoromethylthioindoles by 1,3-dipolar cycloaddition<\/strong>, M. Manneveau<\/span>, B. Rkein, D. Cahard, J. Legros<\/span>, I. Chataigner, J. Flow. Chem.,<\/em> 2022<\/strong> 12, 141 ; DOI : https:\/\/doi.org\/10.1007\/s41981-021-00203-z<\/a><\/p><\/div>\n\n\n\n

Article<\/span> \u00b7 Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry<\/strong>, M. Manneveau<\/span>, S. Tanii, F. Gens, J. Legros<\/span>, I. Chataigner,
<\/strong>Org. Biomol. Chem.<\/em>, 2020<\/strong>, 18, 3481 ; DOI : <\/a>https:\/\/doi.org\/10.1039\/D0OB00582G<\/a><\/p><\/div>\n<\/div><\/div><\/div>\n<\/details>\n\n\n\n

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Publications Synth\u00e8se de principes actifs pharmaceutiques en flux continu Article \u00b7 Process Intensified Continuous Flow Synthesis of Propofol, A. Coeuillas, A. Ceuninck, L. Chausset-Boissarie, J. Legros, P. Jubault, T. Poisson, Org. Process Res. Dev. 2026, XXXX, XXX, XXX-XXX, DOI : https:\/\/doi.org\/10.1021\/acs.oprd.6c00151 Revue \u00b7 Will the next generation of chemical plants be in miniaturized flow reactors?, J.-C. M. Monbaliu, J. Legros,…<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","footnotes":""},"class_list":["post-118","page","type-page","status-publish","hentry"],"featured_image_src":null,"featured_image_src_square":null,"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/pages\/118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/comments?post=118"}],"version-history":[{"count":14,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/pages\/118\/revisions"}],"predecessor-version":[{"id":743,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/pages\/118\/revisions\/743"}],"wp:attachment":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/media?parent=118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}