{"id":770,"date":"2026-09-01T16:45:33","date_gmt":"2026-09-01T14:45:33","guid":{"rendered":"https:\/\/normandyflowchem.univ-rouen.fr\/?p=770"},"modified":"2026-09-01T16:45:33","modified_gmt":"2026-09-01T14:45:33","slug":"3-nouvelles-publications-de-normandyflowchem","status":"publish","type":"post","link":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/3-nouvelles-publications-de-normandyflowchem\/","title":{"rendered":"3 nouvelles publications de NormandyFlowChem"},"content":{"rendered":"

We are glad to share that this summer, three new papers concerning projects carried at NormandyFlowChem were published:<\/p>\n\n\n\n

Process-Intensified Continuous Flow Synthesis of Propofol, OPRD<\/em><\/a><\/h3>\n\n\n\n

The first article presents the process intensification of our continuous flow synthesis of Propofol, an anaesthetic used in intensive care units, is now published in Organic Process Research & Development <\/em>(DOI : https:\/\/doi.org\/10.1021\/acs.oprd.6c00151<\/a>).

This project was conducted by Antoine Coeuillas<\/a>, Aurore CEUNINCK, PhD<\/a>, Laetitia Chausset-Boissarie<\/a>, Julien Legros<\/a>, Philippe Jubault<\/a> and Thomas Poisson<\/a> within NormandyFlowChem<\/a> plateforme ofInstitut CARMeN<\/a>The purpose was to re-optimize our previous 2021 synthesis, with the aim to scale the process while keeping in mind the various industrial constraints. We could increase significatively both productivity and space-time yield of the synthesis, while discarding non-desirables reagents and solvents for industry, resulting in a more sustainable process.

This work has been made possible thanks to NFC plateforme complete range of flow chemisty equipments: Vapourtec Ltd<\/a> systems for initial lab development, then Corning Advanced-Flow Reactors<\/a> (G1) and KHIMOD<\/a> systems for transposition to higher kilolab\/pilot scale.

We also would like to thank Fr\u00e9d\u00e9ric Pin, Sylvie Dhulut and Thibaud Br\u00e9gent from ORIL Industrie for GreenScore calculation, and Eric Aubay<\/a> for the Khimod reactor loan.<\/p>\n\n\n\n

Development and Scale-Up of a Regioselective Functionalization of 2-Cyano-3-fluoropyridine in a Flow Reactor, OPRD<\/em><\/a><\/h3>\n\n\n\n

The second article presents the development and scale-up of a regioselective functionalization of 2-Cyano-3-fluoropyridine, an interesting intermediate towards APIs, is now published in Organic Process Research & Development<\/em> (DOI : https:\/\/doi.org\/10.1021\/acs.oprd.6c00156<\/a>).

This project was conducted by L\u00e9na Brassart<\/a>, Antoine Coeuillas<\/a>, Thomas Poisson<\/a>, Julien Legros<\/a>, Philippe Jubault<\/a> and Laetitia Chausset-Boissarie<\/a> within NormandyFlowChem<\/a> plateforme ofInstitut CARMeN<\/a>in collaboration with Maxime MANNEVEAU<\/a>, Philippe Huez<\/a> and Massimiliano Forcato<\/a> from the pharmaceutical company Zach – Zambon Chemicals<\/a>. Le proc\u00e9d\u00e9 d\u00e9velopp\u00e9 consiste en la g\u00e9n\u00e9ration controll\u00e9e d’un interm\u00e9diaire pyridyllithium par d\u00e9protonation au LDA en conditions non-cryog\u00e9niques puis pi\u00e9gage par l’\u00e9lectrophile d\u00e9sir\u00e9.

La chimie en flux a permis de r\u00e9aliser cette strat\u00e9gie avec une tr\u00e8s bonne s\u00e9lectivit\u00e9 et une bonne productivit\u00e9, ce qui a ensuite rendu possible une transposition homoth\u00e9tique de l’\u00e9chelle du laboratoire (syst\u00e8me LowFlow de Corning Advanced-Flow Reactors<\/a>) \u00e0 plus grande \u00e9chelle (syst\u00e8me G1). La productivit\u00e9 a ainsi pu \u00eatre multipli\u00e9e par 17 sans perte de s\u00e9lectivit\u00e9.<\/p>\n\n\n\n

Nous sommes \u00e9galement ravis de voir que les deux articles ont \u00e9t\u00e9 publi\u00e9s l’un \u00e0 la suite de l’autre dans le dernier num\u00e9ro d’OPRD \ud83d\ude42<\/p>\n\n\n\n

Taming the Halogen Dance of Bromo(Thi)azoles through Flow Microreactors, JOC<\/em><\/a><\/h3>\n\n\n\n

Le troisi\u00e8me article a pour sujet le contr\u00f4le du ph\u00e9nom\u00e8ne de la danse de l’halog\u00e8ne sur des bromo(thi)azoles au moyen de la chimie en flux en continu et son exploitation dans leur fonctionnalisation r\u00e9gios\u00e9lective. Il a \u00e9t\u00e9 publi\u00e9 dans le Journal of Organic Chemistry<\/em> (DOI : https:\/\/doi.org\/10.1021\/acs.joc.6c00972<\/a>).<\/p>\n\n\n\n

This project was conducted by Baran Ozveren<\/a>, Antoine Coeuillas<\/a>, Philippe Jubault<\/a>, Laetitia Chausset-Boissarie<\/a> Thomas Poisson<\/a> and Julien Legros<\/a> within NormandyFlowChem<\/a> plateforme ofInstitut CARMeN<\/a>, en collaboration avec l’entreprise INTEROR<\/a>. <\/p>\n\n\n\n

Les conditions en flux mises au point permettent de favoriser le ph\u00e9nom\u00e8ne de la danse de l’halog\u00e8ne, qui s’appuie sur des \u00e9changes brome-lithium entre un interm\u00e9diaire d\u00e9protonn\u00e9 par du LDA et le substrat de d\u00e9part, de pi\u00e9ger l’interm\u00e9diaire lithi\u00e9 obtenu et d’ainsi arriver plus facilement \u00e0 divers h\u00e9t\u00e9rocycles aromatiques (bi)fonctionnalis\u00e9s avec une tr\u00e8s bonne r\u00e9gioselectivit\u00e9. Cette strat\u00e9gie pourrait ainsi servir d’\u00e9tape-cl\u00e9 dans la synth\u00e8ses de compos\u00e9s h\u00e9t\u00e9roaromatiques complexes.<\/p>\n\n\n\n

Vous pouvez \u00e9galement retrouver le reste de nos r\u00e9alisations \u00e0 cette page<\/a>.<\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

Nous avons le plaisir de partager que cet \u00e9t\u00e9 2026 a vu la publication de trois nouveaux articles issus de travaux r\u00e9alis\u00e9s au sein de la plateforme NormandyFlowChem : Process-Intensified Continuous Flow Synthesis of Propofol, OPRD Le premier article a pour objet notre travail sur l’intensification de la synth\u00e8se en flux continu du Propofol, un anesth\u00e9siant utilis\u00e9 en soins intensifs,…<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[24],"tags":[],"class_list":["post-770","post","type-post","status-publish","format-standard","hentry","category-actualite"],"gutentor_comment":0,"featured_image_src":null,"featured_image_src_square":null,"author_info":{"display_name":"Antoine","author_link":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/author\/coeuiant\/"},"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/posts\/770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/comments?post=770"}],"version-history":[{"count":1,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/posts\/770\/revisions"}],"predecessor-version":[{"id":771,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/posts\/770\/revisions\/771"}],"wp:attachment":[{"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/media?parent=770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/categories?post=770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/normandyflowchem.univ-rouen.fr\/en\/wp-json\/wp\/v2\/tags?post=770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}